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Parkinson’s disease eliminated in mice

“Xiang-Dong Fu, PhD, has never been more excited about something in his entire career. He has long studied the basic biology of RNA, a genetic cousin of DNA, and the proteins that bind it. But a single discovery has launched Fu into a completely new field: neuroscience. 

For decades, Fu and his team at University of California San Diego School of Medicine studied a protein called PTB, which is well known for binding RNA and influencing which genes are turned “on” or “off” in a cell. To study the role of a protein like PTB, scientists often manipulate cells to reduce the amount of that protein, and then watch to see what happens. 

Several years ago, a postdoctoral researcher working in Fu’s lab was taking that approach, using a technique called siRNA to silence the PTB gene in connective tissue cells known as fibroblasts. But it’s a tedious process that needs to be performed over and over. He got tired of it and convinced Fu they should use a different technique to create a stable cell line that’s permanently lacking PTB. At first, the postdoc complained about that too, because it made the cells grow so slowly.

But then he noticed something odd after a couple of weeks — there were very few fibroblasts left. Almost the whole dish was instead filled with neurons.  

In this serendipitous way, the team discovered that inhibiting or deleting just a single gene, the gene that encodes PTB, transforms several types of mouse cells directly into neurons. “

From: UC San Diego New Center – June 24, 2020
https://ucsdnews.ucsd.edu/pressrelease/one-time-treatment-generates-new-neurons-eliminates-parkinsons-disease-in-mice

on: Weaponizing the IRS and Treasury Dept

Congress is attempting to subpoena the tax records of our current president, Donald Trump. Anyone receiving more than a simple paycheck knows how complex the IRS code can be – which was created by Congress. Finding fault will not be difficult when anyone who deals in multiple properties is examined.

But is this a good idea? Who is perfect in all things? Will future presidents face a requirement for perfection in their IRS tax returns? Will a potential good presidential candidate defer from running?

The Gig Harbor Times believes the both democrats and republicans will clobber any future president with IRS tax return attacks if congress is allowed to continue badgering the president about tax returns. Do we really need a future full of income examination attacks on future presidents? When will it stop?

NO DRIVE DAY

Imagine one day per year, then one day/month then one day/week!

This post is dedicated to the idea that we can have one day this year to not drive our fossil fueled cars. It should be a legal holiday in the sense that all fossil fueled cars are required to stay off public roads and highways. (Electric vehicles, public transportation and emergency services excluded.) Oct 10th is just a suggestion.

No Drive Day can be repeated until companies provide electric vans to pick up employees, employees take mass transportation or carpool with electric vehicle owners or work from home.

Industry and business will be against this and pressure congressional representatives with a thousand reasons it won’t work.
Will politicians do anything about it? Could they? Can you? Pass it on.

” Stay away from negative people. They have a problem for every solution. “
– Albert Einstein