University of Minnesota Medical School researchers “showed it was possible to reduce the burden of damaged cells, termed senescent cells, and extend lifespan and improve health, even when treatment was initiated late in life. They now have shown that treatment of aged mice with the natural product Fisetin, found in many fruits and vegetables, also has significant positive effects on health and lifespan.
As people age, they accumulate damaged cells. When the cells get to a certain level of damage they go through an aging process of their own, called cellular senescence. The cells also release inflammatory factors that tell the immune system to clear those damaged cells. A younger person’s immune system is healthy and is able to clear the damaged cells. But as people age, they aren’t cleared as effectively. Thus they begin to accumulate, cause low-level inflammation and release enzymes that can degrade the tissue.
Robbins and fellow researchers found a natural product, called Fisetin, reduces the level of these damaged cells in the body. They found this by treating mice towards the end of life with this compound and see improvement in health and lifespan. The paper, “Fisetin is a senotherapeutic that extends health and lifespan,” was recently published in EBioMedicine.“
Read the full article here: https://www.med.umn.edu/news-events/university-minnesota-medical-school-researchers-have-discovered-how-slow-aging
Violent video game play and aggressive behavior have a relationship according to reports in Scientific American and Dartmouth College. Both reports are based on a study by Proceedings of the National Academy of Sciences (1)
The Gig Harbor Times published a list of violent video games available for viewing on YouTube was in 2012 titled “Fixing the mass murder mentality“.
The following are science based articles regarding life extension. Readers should avoid taking nutritional supplements based on any of these articles until additional research proves them safe. Most of the articles were published in 2018. However, some articles are included in this post to reinforce or show history of the progress.
This article can be discussed in the Gig Harbor Message Board along with updates.
MASSACHUSETTS INSTITUTE OF TECHNOLOGY:
“Fasting boosts stem cells’ regenerative capacity
A drug treatment that mimics fasting can also provide the same benefit, study finds”
SCIENTIFIC AMERICAN (guest blog):
“Beyond Resveratrol: The Anti-Aging NAD Fad”
US LIBRARY OF MEDICINE (Abstract)
“Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2.”
Layman’s english: https://theconversation.com/ageing-in-human-cells-successfully-reversed-in-the-lab-101214
UNIVERSITY OF EXETER:
“Key aspects of human cell ageing reversed by new compounds”
“Longevity extension in Drosophila through gut-brain communication”
Layman’s english: https://www.mcgill.ca/newsroom/channels/news/secret-longevity-microbiome-and-gut-287429
UNIVERSITY OF COLORADO BOULDER:
“A pill that staves off aging? It’s on the horizon”
UNIVERSITY OF GOTHENBURG:
“Live longer with fewer calories” (note: published in 2011)
“Scripps Research, Mayo Clinic Scientists Find New Class of Drugs that Dramatically Increases Healthy Lifespan”
NATIONAL INSTITUTES OF HEALTH:
“Senolytic drugs reverse damage caused by senescent cells in mice”